Research

Intrinsically disordered regions are especially common in the nuclear proteome. They play a variety of roles, like connecting specific effector domains into large multi-subunit complexes or facilitating frequent, short-lived interactions with DNA and other chromatin-associated factors. Our research aims to thoroughly understand how these disordered regions help form biomolecular complexes linked to transcription. We explore their roles in various assemblies, nucleosome remodeling, and managing epigenetic marks. Our ultimáte goal is to shed light on how these dynamic elements contribute to the regulation of eukaryotic gene expression.